Quantification of GABA, glutamate and glutamine in a single measurement at 3 T using GABA-edited MEGA-PRESS
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چکیده
منابع مشابه
Quantification of GABA, glutamate and glutamine in a single measurement at 3 T using GABA‐edited MEGA‐PRESS
γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS). In a GABA-edited MEGA-PRESS spectrum, Glu and Gln co-...
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Introduction Glutamate (Glu) and glutamine (Gln) are two major neurochemicals in the central nervous system. Quantifying Glu and Gln in vivo using magnetic resonance spectroscopy (MRS) has been of particular interest to basic science for understanding the Glu/Gln component of the Krebs cycle and its alteration by neuropsychiatric disorders such as Alzheimer’s disease, epilepsy and alcoholism. H...
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PURPOSE To measure in vivo brain gamma-aminobutyric acid (GABA) concentrations, and assess regional and hemispheric differences, using MR spectroscopy (1 H-MRS). MATERIALS AND METHODS GABA concentrations were measured bilaterally in the frontal cortex (FC), parietal cortex (PC), and occipital cortex (OC) of 21 healthy young subjects (age range 20-29 years) using 3 Tesla Philips scanner. A uni...
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The reproducibility of gamma-aminobutyric acid (GABA) quantification results, obtained with MRSI, was determined on a 3 T MR scanner in healthy adults. In this study, a spiral-encoded, GABA-edited, MEGA-LASER MRSI sequence with real-time motion-scanner-instability corrections was applied for robust 3D mapping of neurotransmitters in the brain. In particular, the GABA+ (i.e. GABA plus macromolec...
متن کاملModeling MEGA-PRESS macromolecules for a better grasp of GABA
Introduction: GABA (γ-aminobutyric acid) is a primary inhibitory neurotransmitter in the human brain and the object of many a spectroscopic quest. A MEGAPRESS sequence [1] with TE=68 ms and interleaved selective inversion at 1.9 ppm and 7.5 ppm has been shown to be a useful technique for measuring GABA at 3T, and LCModel [2] can then be used to analyze the resulting difference spectra. A compli...
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ژورنال
عنوان ژورنال: NMR in Biomedicine
سال: 2017
ISSN: 0952-3480
DOI: 10.1002/nbm.3847